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MICROPARTICULE POROASE ZWITERIONICE CARE CONȚIN ZEINĂ ȘI UNITĂȚI BETAINICE, CU ACTIVITATE ANTIMICROBIANĂ ȘI CAPACITATE DE ADMINISTRARE DE MEDICAMENTE
Status proiect: Finalizat
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Articole în reviste cotate ISI

  1. S. Racovita, M.-A. Trofin, A.-L. Vasiliu, M. Avadanei, D. F. Loghin, M. Mihai, S. Vasiliu. Studies on Sorption and Release of Doxycycline Hydrochloride from Zwitterionic Microparticles with Carboxybetaine Moieties, Int. J. Mol. Sci. 25(14), 7871, 2024 (FI2022 = 4.9) (Q1)   https://doi.org/10.3390/ijms25147871  
  2. M.-A. Trofin, S. Racovita, M.I. Avadanei, I. Stoica, I. Rosca, A.-L. Vasiliu, M. Mihai, S. Vasiliu. Design of new zwitterionic microparticles with intrinsicantibacterial activity, J. Polym. Sci., 62, 2129-2146, 2024 (FI2022 = 3.9) (Q2) https://doi.org/10.1002/pol.20230915  
  3. M.-M. Zaharia, F. Bucatariu, A.-L. Vasiliu, M. Mihai. Versatile Zwitterionic Beads for Heavy Metal Ion Removal from Aqueous Media and Soils by Sorption and Catalysis Processes, ACS Applied Polymer Materials, 5, 8183-8193, 2023 (FI2022 = 5) (Q1) https://doi.org/10.1021/acsapm.3c01375
  4. M.-A. Trofin, S. Racovita, S. Vasiliu, A. Bargan, F. Bucatariu, A. L. Vasiliu, M. Mihai. Synthesis of Crosslinked Microparticles Based on GlycidylMethacrylate and N-Vinylimidazole, Macromolecular Chemistry and Physics, 2300253, 2023  (FI2021 = 2,5) (Q2) https://doi.org/10.1002/macp.202300253
  5. M.-A. Trofin, S. Racovita, S. Vasiliu, A. L. Vasiliu, M. Mihai. Porous crosslinked zwitterionic microparticles based on glycidyl methacrylate and N-vinylimidazole as possible drug delivery systems, International Journal of Molecular Sciences 23, 14999, 2022, (FI2021 = 6,208) (Q1) https://doi.org/10.3390/ijms232314999
  6. L.-M. Petrila, V.R. Gradinaru, F. Bucatariu, M. Mihai. Polymer/Enzyme Composite Materials – Versatile Catalysts with Multiple Applications, Chemistry 4(4), 1312-1338, 2022 (FI2021 = 2,1) https://doi.org/10.3390/chemistry4040087
  7. D. F. Loghin, M. M. Bazarghideanu, S. Vasiliu, S. Racovita, M.-M. Zaharia, T. Vasiliu, M. Mihai. Hydrogel Beads of Amidoximated Starch and Chitosan as Efficient Sorbents for Inorganic and Organic Compounds, Gels 8, 549, 2022 (FI2021 = 4,432) (Q1) https://doi.org/10.3390/gels8090549
  8. M.-M. Zaharia, C.-A. Ghiorghita, M.-A. Trofin, F. Doroftei, I. Rosca, M. Mihai. Multifunctional composites of zwitterionic resins and silver nanoparticles for point-of-demand antimicrobial applications, Materials Chemistry and Physics 275, 125225, 2022 (FI2021 = 4,778) (Q2) https://doi.org/10.1016/j.matchemphys.2021.125225
  9. S. Racovita, M.-A. Trofin, D. F. Loghin, M.-M. Zaharia, F. Bucatariu, M. Mihai, S. Vasiliu. Polybetaines in Biomedical Applications, International Journal of Molecular Sciences 22, 9321, 2021 (Review) (FI2020 = 5,924) (Q1) https://doi.org/10.3390/ijms22179321
  10. M.-M. Zaharia, A.-L. Vasiliu, M.-A. Trofin, D. Pamfil, F. Bucatariu, S. Racovita, M. Mihai. Design of multifunctional composite materials based on acrylic ion exchangers and CaCO3 as sorbents for small organic molecules, Reactive and Functional Polymers 166, 104997, 2021 (FI2020 = 3,975) (Q1) https://doi.org/10.1016/j.reactfunctpolym.2021.104997

Articole în proceedings

  1. A.-L. Vasiliu, E.-D. Lotos, M.-M. Zaharia, M. Mihai, Composite hydrogels based on alginates and calcium carbonate, Proceedings of International Conference Progress in Organic Macromolecular Compounds, ISSN 2810 – 2347 ISSN – L 2810 – 2126, 77-80, 2023 https://icmpp.ro/macroiasi2023/files/volum%20proceedings.v6.pdf
  2. E.-D. Lotos, A.-L. Vasiliu, M. Mihai, B. C. Simionescu, Nonstoichiometric polyelectrolyte complex nanoparticles based on zein and polysaccharides, Proceedings of International Conference Progress in Organic Macromolecular Compounds, ISSN 2810 – 2347 ISSN – L 2810 – 2126, 92-95, 2023 https://icmpp.ro/macroiasi2023/files/volum%20proceedings.v6.pdf
  3. L.-M. Petrila, M.-M. Zaharia, F. Bucatariu, M. Mihai, S. Pispas, Exploring the remarkable properties of water soluble chitosans, Proceedings of International Conference Progress in Organic Macromolecular Compounds, ISSN 2810 – 2347 ISSN – L 2810 – 2126, 102-105, 2023 https://icmpp.ro/macroiasi2023/files/volum%20proceedings.v6.pdf
  4. M.M. Bazarghideanu, D. F. Loghin,  M. Mihai, Removal cobalt from polluted water using microspheres of amidoximated starch and chitosan, 12th International Conference on Environmental Engineering and Management, ISSN 2457-7049, ISSN – L 2457-7049, 161-162, 2023.
  5. L.-M. Petrila, F. Bucatariu, M.-M. Zaharia, M. Mihai, Separation and water cleaning by composites of polyelectrolytes and inorganic microparticles, 12th International Conference on Environmental Engineering and Management, ISSN 2457-7049, ISSN – L 2457-7049, 195-196, 2023.
  6. M.-M. Zaharia, A.-L. Vasiliu, F. Bucatariu, M. Mihai, Zwitterionic polymeric beads as sorbents for heavy metal ions from Tarnita surface water: fluidized bed column studies, 12th International Conference on Environmental Engineering and Management, ISSN 2457-7049, ISSN – L 2457-7049, 177-178, 2023.
  7. M. Mihai, Polyelectrolyte-based composite materials for targeted environmental applications, 12th International Conference on Environmental Engineering and Management, ISSN 2457-7049, ISSN – L 2457-7049, 23-24, 2023.
  8. M.-A. Trofin, S. Racovita, S. Vasiliu, A.-L. Vasiliu, D. F. Loghin, O. Boita, M. Mihai, New zwitterionic copolymer with carboxybetaine moieties as possible drug delivery system, Proceedings of International Conference Progress in Organic Macromolecular Compounds, ISSN 2810 – 2347 ISSN – L 2810 – 2126, 131-132, 2021 https://icmpp.ro/macroiasi2023/files/proceedings-POMC.pdf
  9. M.-M. Zaharia, A.-L. Vasiliu, M.-A. Trofin, M.-M. Bazarghideanu, C. Blegescu, M. Mihai. Synthesis and characterization of acrylic ion exchange resins and their environmental applications as sorbents, Proceedings of International Conference Progress in Organic Macromolecular Compounds, ISSN 2810 – 2347, ISSN – L 2810 – 2126, 123-124, 2021 https://icmpp.ro/macroiasi2023/files/proceedings-POMC.pdf

Participări la manifestări științifice 

  1. E.-D. Lotos, M. Karayianni, A.-L. Vasiliu, L.-M. Petrila, M. Mihai, B. C. Simionescu, S. Pispas, Interaction between water-soluble chitosan and thermo-responsive poly(n-isopropylacrylamide), ICMPP – Open Door to The Future. Scientific Communications of Young Researchers with international participation, 4th Edition MacroYouth 2023, Iasi, Romania, 17 November 2023 (Oral communication).
  2. L.-M. Petrila, M.-M. Zaharia, F. Bucatariu, M. Mihai, S. Pispas, Exploring the remarkable properties of water soluble chitosans, 29th edition of the Progress in Organic and Macromolecular Compounds Conference, MACRO Iasi 2023, Iasi, Romania, 4-6 October 2023 (Poster presentation).
  3. E.-D. Lotos, A.-L. Vasiliu, M. Mihai, B. C. Simionescu, Nonstoichiometric polyelectrolyte complex nanoparticles based on zein and polysaccharides, 29th edition of the Progress in Organic and Macromolecular Compounds Conference, MACRO Iasi 2023, Iasi, Romania, 4-6 October 2023 (Oral communication).
  4. A.-L. Vasiliu, E.-D. Lotos, M.-M. Zaharia, M. Mihai, Composite hydrogels based on alginates and calcium carbonate, 29th edition of the Progress in Organic and Macromolecular Compounds Conference, MACRO Iasi 2023, Iasi, Romania, 4-6 October 2023 (Oral communication).
  5. M. Mihai, (Multi)functional Ionic Polymers. From Synthesis to Materials Design, 29th PolyChar World Forum on Advanced Materials, Nice, Franta, 26-29 September 2023 (Oral communication).
  6. E.-D. Lotos, M. Mihai, A.-L. Vasiliu, B. C. Simionescu, Zein/ Polysaccharide Nanoparticles as Drug Delivery Systems, 29th PolyChar World Forum on Advanced Materials, Nice, Franta, 26-29 September 2023 (Oral communication).
  7. M.-M. Bazarghideanu, D. F. Loghin, M. Mihai, Removal cobalt from polluted water using microspheres of amidoximated starch and chitosan, 12th International Conference on Environmental Engineering and Management (ICEEM12), Iasi, Romania, 13-16 September 2023 (Oral communication).
  8. M.-M. Zaharia, A.-L. Vasiliu, F. Bucatariu, M. Mihai, Zwitterionic polymeric beads as sorbents for heavy metal ions from Tarnita surface water: fluidized bed column studies, 12th International Conference on Environmental Engineering and Management (ICEEM12), Iasi, Romania, 13-16 September 2023 (Oral communication).
  9. M. Mihai, Polyelectrolyte-based composite materials for targeted environmental applications, 12th International Conference on Environmental Engineering and Management (ICEEM12), Iasi, Romania, 13-16 September 2023 (Keynote lecture).
  10. M.-A. Trofin, S. Racovita, A.-L. Vasiliu, S. Vasiliu, M. Mihai, Porous crosslinked microparticles based on glycidyl methacrylate and N-vinylimidazole as precursors for advanced polymeric materials, 12th International Conference on Materials Science and Engineering (BRAMAT), Brașov, România, 9-12 Martie 2022 (comunicare orală).
  11. M.-A. Trofin, S. Vasiliu, S. Racovita, M. Mihai, Release studies of tetracycline from zwitterionic crosslinked copolymer with carboxybetaine units, NeXT Chem – Tehnologii inovatoare trans-sectoriale – Ediția a IV-a, București, România, 19-20 Mai 2022 (comunicare orală).
  12. M.-A. Trofin, S. Racovita, A.-L. Vasiliu, S. Vasiliu, M. Mihai, New hybrid crosslinked microparticles containing zein for drug delivery; 20th National Symposium Polymers 2022 open to International Participation (POLYMERS 2022), Velingrad, Bulgaria, 5-8 Iulie 2022 (comunicare orală).
  13. E.-D. Lotos, A.-L. Vasiliu, B. C. Simionescu, M. Mihai, Composite particles based on zein and polysaccharides; 20th National Symposium Polymers 2022 open to International Participation (POLYMERS 2022), Velingrad, Bulgaria, 5-8 Iulie 2022 (comunicare orală).
  14. M. Mihai, Polyelectrolyte-based architectures for targeted applications in water cleaning and medicine, 20th National Symposium Polymers 2022 open to International Participation (POLYMERS 2022), Velingrad, Bulgaria, 5-8 Iulie 2022 (keynote invitat).
  15. M. Mihai, Polyelectrolytes in multicomponent systems. Application in water cleaning and medicine, Conferinta Nationala de Chimie, Calimăneşti Căciulata, România, 04-07 Octombrie 2022,  (conferință plenară).
  16. M. Mihai, (Multi)functional ionic polymers. synthesis, materials design, application, New Trends and Strategies in the Chemistry of Advanced Materials with Relevance in Biological Systems, Technique and Environmental Protection, Timișoara, România, 20-21 Octombrie 2022,  (conferință plenară).
  17. M.-A. Trofin, M. Karayianni, S. Vasiliu, S. Racoviță, M. Mihai, S. Pispas, Zwitterionic grafted gellan: synthesis, solution and gel properties, ICMPP – Open Door to The Future. 3rd Edition Scientific Communications of Young Researchers (MacroYouth’2022), Iasi, Romania, 18 Noiembrie 2022, (comunicare orală).
  18. A.-L. Vasiliu, M.-M. Zaharia, M. Mihai, Ionic beads/CaCO3 composites as sorbents for small organic molecules, ICMPP-OPEN DOOR TO THE FUTURE-Scientific Communications of Young Researchers, 2nd Edition (MacroYouth’2021), Iasi, Romania, 19 Noiembrie 2021 (comunicare orală).
  19. M.-A. Trofin, S. Racovita, S. Vasiliu, A.-L. Vasiliu, D. F. Loghin, O. Boita, M. Mihai, New zwitterionic copolymer with carboxybetaine moietes as possible drug delivery system, Progress in Organic and Macromolecular Compounds 28th  edition MACRO Iasi 2021, 7-9 Octombrie 2021 (poster). 
  20. M.-M. Zaharia, A.-L. Vasiliu, M.-A. Trofin, M.-M. Bazarghideanu, C. Blegescu, M. Mihai, Synthesis and characterization of acrylic ion exchange resins and their environmental applications as sorbent, Progress in Organic and Macromolecular Compounds 28th  edition MACRO Iasi 2021, 7-9 Octombrie 2021 (poster). 
  21. A.-L. Vasiliu, M.-A. Trofin, S. Vasiliu, Ș. Racoviță, D. F. Loghin, M. Mihai, Soft materials as zwitterionic porous microparticles with drug delivery capabilities, International Conference on Interfaces, Santa Margherita, Sardinia, Italy,  21–25 Septembrie 2021 (poster).
  22. M. Mihai, M.-M. Zaharia, C.-A. Ghiorghita, M. M. Bzarghideanu, A.-L. Vasiliu, M.-A. Trofin. Nano-silver in-situ synthesis in zwitterionic beads, as antimicrobial inorganic/organic composites, Materials, Methods & Technologies 23rd International Conference, Burgas, Bulgaria, 19-22 August 2021 (comunicare orală).
  23. M.-A. Trofin, S. Vasiliu, S. Racovita, M. Mihai. Zwitterionic porous microparticles containing betaine units with drug delivery capabilities, Materials, Methods & Technologies 23rd International Conference, Burgas, Bulgaria, 19-22 August 2021 (comunicare orală).

Elaborarea unei teze de doctorat pe tema proiectului ZwitterZein

  1. Materiale zwiterionice cu proprietăți antimicrobiene și/sau purtători de principii biologic active, Doctorand Marin-Aurel TROFIN, Conducător de doctorat Dr. Habil. Marcela MIHAI (https://icmpp.ro/ro/sustineri_doctorate.php)

Stagiu scurt de cercetare pentru specializarea unui membru al echipei

  1. Doctorand Marin-Aurel TROFIN
    Locație: Institutul de Chimie Teoretică și Fizică al Fundației Naționale Elene de Cercetare, din Atena, Grecia, sub coordonarea dr. Stergios Pispas
    Perioada: 17.09 – 17.10.2022
    Scopul deplasarii: Traing pentru tehnicile de Dynamic Light Scattering, spectrosopie de fluorescență si UV-Vis, spectroscopie FTIR, determinare potențial zeta. Pe parcursul stagiului au fost analizate câteva probe reprezentative pregătite pe cadrul proiectului.
  2. Doctorand Elena-Daniela LOTOS
    Locație: Institutul de Polimeri al Academiei de Științe a Bulgariei, din Sofia, Bulgaria, Laboratorul de Polimeri Bioactivi, sub coordonarea prof.dr. Olya Stoilova
    Perioada: 09.05.2022- 08.06.2022
    Scopul deplasarii: Materiale polimerice poroase pentru aplicații în medicină și protecția mediului. Training în tehnica electrofilării. Pe parcursul stagiului au fost analizate câteva probe reprezentative pregătite pe cadrul proiectului.
  3. Doctorand Marin-Aurel TROFIN
    Locație: Leibniz-Institut für Polymerforschung e.V., Dresda, Germania, în cadrul Departamentului de Interfețe Polimerice, dr. Frank Simon
    Perioada: 25.10-07.11.2021
    Scopul deplasarii: Traing pentru tehnicile de spectroscopie de fotoelectroni cu raze X (XPS) și de investigaţii electrocinetice ale suprafeţelor solide. 
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