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Zwitterionic porous microparticles containing zein and betaine moieties with antimicrobial activity and drug delivery capabilities
Project status: Ended
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Articles in ISI ranked journals

  1. S. Racovita, M.-A. Trofin, A.-L. Vasiliu, M. Avadanei, D. F. Loghin, M. Mihai, S. Vasiliu. Studies on Sorption and Release of Doxycycline Hydrochloride from Zwitterionic Microparticles with Carboxybetaine Moieties, Int. J. Mol. Sci. 25(14), 7871, 2024 (FI2022 = 4.9) (Q1)   https://doi.org/10.3390/ijms25147871 
  2. M.-A. Trofin, S. Racovita, M.I. Avadanei, I. Stoica, I. Rosca, A.-L. Vasiliu, M. Mihai, S. Vasiliu. Design of new zwitterionic microparticles with intrinsicantibacterial activity, J. Polym. Sci, 62, 2129-2146, 2024 (FI2022 = 3.9) (Q2) https://doi.org/10.1002/pol.20230915 
  3. M.-M. Zaharia, F. Bucatariu, A.-L. Vasiliu, M. Mihai. Versatile Zwitterionic Beads for Heavy Metal Ion Removal from Aqueous Media and Soils by Sorption and Catalysis Processes, ACS Applied Polymer Materials, 5, 8183-8193, 2023 (FI2022 = 5) (Q1) https://doi.org/10.1021/acsapm.3c01375
  4. M.-A. Trofin, S. Racovita, S. Vasiliu, A. Bargan, F. Bucatariu, A. L. Vasiliu, M. Mihai. Synthesis of Crosslinked Microparticles Based on GlycidylMethacrylate and N-Vinylimidazole, Macromolecular Chemistry and Physics, 2300253, 2023  (FI2021 = 2,5) (Q2) https://doi.org/10.1002/macp.202300253
  5. M.-A. Trofin, S. Racovita, S. Vasiliu, A. L. Vasiliu, M. Mihai. Porous crosslinked zwitterionic microparticles based on glycidyl methacrylate and N-vinylimidazole as possible drug delivery systems, Int. J. Mol. Sci. 23, 14999, 2022 (FI2021 = 6,208) (Q1) https://doi.org/10.3390/ijms232314999
  6. L.-M. Petrila, V.R. Gradinaru, F. Bucatariu, M. Mihai. Polymer/Enzyme Composite Materials – Versatile Catalysts with Multiple Applications, Chemistry 4(4), 1312-1338, 2022 (FI2021 = 2,1) https://doi.org/10.3390/chemistry4040087
  7. D. F. Loghin, M. M. Bazarghideanu, S. Vasiliu, S. Racovita, M.-M. Zaharia, T. Vasiliu, M. Mihai. Hydrogel Beads of Amidoximated Starch and Chitosan as Efficient Sorbents for Inorganic and Organic Compounds, Gels 8, 549, 2022 (FI2021 = 4,432) (Q1) https://doi.org/10.3390/gels8090549
  8. M.-M. Zaharia, C.-A. Ghiorghita, M.-A. Trofin, F. Doroftei, I. Rosca, M. Mihai. Multifunctional composites of zwitterionic resins and silver nanoparticles for point-of-demand antimicrobial applications, Materials Chemistry and Physics 275, 125225, 2022 (FI2021= 4,778) (Q2) https://doi.org/10.1016/j.matchemphys.2021.125225
  9. S. Racovita, M.-A. Trofin, D. F. Loghin, M.-M. Zaharia, F. Bucatariu, M. Mihai, S. Vasiliu. Polybetaines in Biomedical Applications, International Journal of Molecular Sciences 22, 9321, 2021 (Review) (FI2020 = 5,924) (Q1) https://doi.org/10.3390/ijms22179321
  10. M.-M. Zaharia, A.-L. Vasiliu, M.-A. Trofin, D. Pamfil, F. Bucatariu, S. Racovita, M. Mihai. Design of multifunctional composite materials based on acrylic ion exchangers and CaCO3 as sorbents for small organic molecules, Reactive and Functional Polymers 166, 104997, 2021 (FI2020 = 3,975) (Q1) https://doi.org/10.1016/j.reactfunctpolym.2021.104997

Articles in proceedings

  1. A.-L. Vasiliu, E.-D. Lotos, M.-M. Zaharia, M. Mihai, Composite hydrogels based on alginates and calcium carbonate, Proceedings of International Conference Progress in Organic Macromolecular Compounds, ISSN 2810 – 2347 ISSN – L 2810 – 2126, 77-80, 2023 https://icmpp.ro/macroiasi2023/files/volum%20proceedings.v6.pdf
  2. E.-D. Lotos, A.-L. Vasiliu, M. Mihai, B. C. Simionescu, Nonstoichiometric polyelectrolyte complex nanoparticles based on zein and polysaccharides, Proceedings of International Conference Progress in Organic Macromolecular Compounds, ISSN 2810 – 2347 ISSN – L 2810 – 2126, 92-95, 2023 https://icmpp.ro/macroiasi2023/files/volum%20proceedings.v6.pdf
  3. L.-M. Petrila, M.-M. Zaharia, F. Bucatariu, M. Mihai, S. Pispas, Exploring the remarkable properties of water soluble chitosans, Proceedings of International Conference Progress in Organic Macromolecular Compounds, ISSN 2810 – 2347 ISSN – L 2810 – 2126, 102-105, 2023 https://icmpp.ro/macroiasi2023/files/volum%20proceedings.v6.pdf
  4. M.M. Bazarghideanu, D. F. Loghin,  M. Mihai, Removal cobalt from polluted water using microspheres of amidoximated starch and chitosan, 12th International Conference on Environmental Engineering and Management, ISSN 2457-7049, ISSN – L 2457-7049, 161-162, 2023.
  5. L.-M. Petrila, F. Bucatariu, M.-M. Zaharia, M. Mihai, Separation and water cleaning by composites of polyelectrolytes and inorganic microparticles, 12th International Conference on Environmental Engineering and Management, ISSN 2457-7049, ISSN – L 2457-7049, 195-196, 2023.
  6. M.-M. Zaharia, A.-L. Vasiliu, F. Bucatariu, M. Mihai, Zwitterionic polymeric beads as sorbents for heavy metal ions from Tarnita surface water: fluidized bed column studies, 12th International Conference on Environmental Engineering and Management, ISSN 2457-7049, ISSN – L 2457-7049, 177-178, 2023.
  7. M. Mihai, Polyelectrolyte-based composite materials for targeted environmental applications, 12th International Conference on Environmental Engineering and Management, ISSN 2457-7049, ISSN – L 2457-7049, 23-24, 2023.
  8. M.-A. Trofin, S. Racovita, S. Vasiliu, A.-L. Vasiliu, D. F. Loghin, O. Boita, M. Mihai, New zwitterionic copolymer with carboxybetaine moieties as possible drug delivery system, Proceedings of International Conference Progress in Organic Macromolecular Compounds, ISSN 2810 – 2347 ISSN – L 2810 – 2126, 131-132, 2021 https://icmpp.ro/macroiasi2023/files/proceedings-POMC.pdf
  9. M.-M. Zaharia, A.-L. Vasiliu, M.-A. Trofin, M.-M. Bazarghideanu, C. Blegescu, M. Mihai. Synthesis and characterization of acrylic ion exchange resins and their environmental applications as sorbents, Proceedings of International Conference Progress in Organic Macromolecular Compounds, ISSN 2810 – 2347, ISSN – L 2810 – 2126, 123-124, 2021 https://icmpp.ro/macroiasi2023/files/proceedings-POMC.pdf

Participation at scientific meetings

  1. E.-D. Lotos, M. Karayianni, A.-L. Vasiliu, L.-M. Petrila, M. Mihai, B. C. Simionescu, S. Pispas, Interaction between water-soluble chitosan and thermo-responsive poly(n-isopropylacrylamide), ICMPP – Open Door to The Future. Scientific Communications of Young Researchers with international participation, 4th Edition MacroYouth 2023, Iasi, Romania, 17 November 2023 (Oral communication).
  2. L.-M. Petrila, M.-M. Zaharia, F. Bucatariu, M. Mihai, S. Pispas, Exploring the remarkable properties of water soluble chitosans, 29th edition of the Progress in Organic and Macromolecular Compounds Conference, MACRO Iasi 2023, Iasi, Romania, 4-6 October 2023 (Poster presentation).
  3. E.-D. Lotos, A.-L. Vasiliu, M. Mihai, B. C. Simionescu, Nonstoichiometric polyelectrolyte complex nanoparticles based on zein and polysaccharides, 29th edition of the Progress in Organic and Macromolecular Compounds Conference, MACRO Iasi 2023, Iasi, Romania, 4-6 October 2023 (Oral communication).
  4. A.-L. Vasiliu, E.-D. Lotos, M.-M. Zaharia, M. Mihai, Composite hydrogels based on alginates and calcium carbonate, 29th edition of the Progress in Organic and Macromolecular Compounds Conference, MACRO Iasi 2023, Iasi, Romania, 4-6 October 2023 (Oral communication).
  5. M. Mihai, (Multi)functional Ionic Polymers. From Synthesis to Materials Design, 29th PolyChar World Forum on Advanced Materials, Nice, Franta, 26-29 September 2023 (Oral communication).
  6. E.-D. Lotos, M. Mihai, A.-L. Vasiliu, B. C. Simionescu, Zein/ Polysaccharide Nanoparticles as Drug Delivery Systems, 29th PolyChar World Forum on Advanced Materials, Nice, Franta, 26-29 September 2023 (Oral communication).
  7. M.-M. Bazarghideanu, D. F. Loghin, M. Mihai, Removal cobalt from polluted water using microspheres of amidoximated starch and chitosan, 12th International Conference on Environmental Engineering and Management (ICEEM12), Iasi, Romania, 13-16 September 2023 (Oral communication).
  8. M.-M. Zaharia, A.-L. Vasiliu, F. Bucatariu, M. Mihai, Zwitterionic polymeric beads as sorbents for heavy metal ions from Tarnita surface water: fluidized bed column studies, 12th International Conference on Environmental Engineering and Management (ICEEM12), Iasi, Romania, 13-16 September 2023 (Oral communication).
  9. M. Mihai, Polyelectrolyte-based composite materials for targeted environmental applications, 12th International Conference on Environmental Engineering and Management (ICEEM12), Iasi, Romania, 13-16 September 2023 (Keynote lecture).
  10. M.-A. Trofin, S. Racovita, A.-L. Vasiliu, S. Vasiliu, M. Mihai, Porous crosslinked microparticles based on glycidyl methacrylate and N-vinylimidazole as precursors for advanced polymeric materials, 12th International Conference on Materials Science and Engineering (BRAMAT), Brașov, România, 9-12 March 2022 (Oral communication).
  11. M.-A. Trofin, S. Vasiliu, S. Racovita, M. Mihai, Release studies of tetracycline from zwitterionic crosslinked copolymer with carboxybetaine units, NeXT Chem – Tehnologii inovatoare trans-sectoriale – Ediția a IV-a, București, România, 19-20 May 2022 (Oral communication).
  12. M.-A. Trofin, S. Racovita, A.-L. Vasiliu, S. Vasiliu, M. Mihai, New hybrid crosslinked microparticles containing zein for drug delivery; 20th National Symposium Polymers 2022 open to International Participation (POLYMERS 2022), Velingrad, Bulgaria, 5-8 July 2022 (Oral communication).
  13. E.-D. Lotos, A.-L. Vasiliu, B. C. Simionescu, M. Mihai, Composite particles based on zein and polysaccharides; 20th National Symposium Polymers 2022 open to International Participation (POLYMERS 2022), Velingrad, Bulgaria, 5-8 July 2022 (Oral communication).
  14. M. Mihai, Polyelectrolyte-based architectures for targeted applications in water cleaning and medicine, 20th National Symposium Polymers 2022 open to International Participation (POLYMERS 2022), Velingrad, Bulgaria, 5-8 July 2022 (Invited lectures).
  15. M. Mihai, Polyelectrolytes in multicomponent systems. Application in water cleaning and medicine, Conferinta Nationala de Chimie, Calimăneşti Căciulata, România, 04-07 October 2022 (Lectures).
  16. M. Mihai, (Multi)functional ionic polymers. synthesis, materials design, application, New Trends and Strategies in the Chemistry of Advanced Materials with Relevance in Biological Systems, Technique and Environmental Protection, Timișoara, România, 20-21 October 2022  (Lectures).
  17. M.-A. Trofin, M. Karayianni, S. Vasiliu, S. Racoviță, M. Mihai, S. Pispas, Zwitterionic grafted gellan: synthesis, solution and gel properties, ICMPP – Open Door to The Future. 3rd Edition Scientific Communications of Young Researchers (MacroYouth’2022), Iasi, Romania, 18 November 2022 (Oral communication).
  18. A.-L. Vasiliu, M.-M. Zaharia, M. Mihai, Ionic beads/CaCO3 composites as sorbents for small organic molecules, ICMPP-OPEN DOOR TO THE FUTURE-Scientific Communications of Young Researchers, 2nd Edition (MacroYouth’2021), Iasi, Romania, 19 November 2021 (Oral communication).
  19. M.-A. Trofin, S. Racovita, S. Vasiliu, A.-L. Vasiliu, D. F. Loghin, O. Boita, M. Mihai, New zwitterionic copolymer with carboxybetaine moietes as possible drug delivery system, Progress in Organic and Macromolecular Compounds 28th  edition MACRO Iasi 2021, 7-9 October 2021 (Poster).
  20. M.-M. Zaharia, A.-L. Vasiliu, M.-A. Trofin, M.-M. Bazarghideanu, C. Blegescu, M. Mihai, Synthesis and characterization of acrylic ion exchange resins and their environmental applications as sorbent, Progress in Organic and Macromolecular Compounds 28th  edition MACRO Iasi 2021, 7-9 October 2021 (Poster).
  21. A.-L. Vasiliu, M.-A. Trofin, S. Vasiliu, Ș. Racoviță, D. F. Loghin, M. Mihai, Soft materials as zwitterionic porous microparticles with drug delivery capabilities, International Conference on Interfaces, Santa Margherita, Sardinia, Italy,  21–25 September 2021 (Poster).
  22. M. Mihai, M.-M. Zaharia, C.-A. Ghiorghita, M. M. Bzarghideanu, A.-L. Vasiliu, M.-A. Trofin. Nano-silver in-situ synthesis in zwitterionic beads, as antimicrobial inorganic/organic composites, Materials, Methods & Technologies 23rd International Conference, Burgas, Bulgaria, 19-22 August 2021 (Oral Communication).
  23. M.-A. Trofin, S. Vasiliu, S. Racovita, M. Mihai. Zwitterionic porous microparticles containing betaine units with drug delivery capabilities, Materials, Methods & Technologies 23rd International Conference, Burgas, Bulgaria, 19-22 August 2021 (Oral Communication).

 

Elaboration of a doctoral thesis directly related to the subject of the project

  1. Porous zwitterionic microparticles with antimicrobial activity and the ability to administer drugs, PhD student Marin-Aurel TROFIN, scientific supervisor Dr. Habil. Marcela MIHAI (https://icmpp.ro/theses_announcements.php)

 

Short research internship for the specialization of a team member

  1. Doctoral student Marin-Aurel TROFIN
    Location: Theoretical and Physical Chemistry Institute, National Hellenic Research Foundation, Athens, Greece, Dr. Stergios Pispas
    Period: 17.09 – 17.10.2022
    Theme: Short training for Dynamic Light Scattering, fluorescence, Uv-Vis and FT-IR spectroscopy and zeta potential. 
  2. Doctoral student Elena-Daniela LOTOS
    Location: Institute of Polymers, Bulgarian Academy of Science, Sofia, Bulgaria, Dr. Olya Stoilova
    Period: 09.05.2022- 08.06.2022
    Theme: Porous polymeric materials for medical and environmental applications. Short training for electrospinning. 
  3. Doctoral student Marin-Aurel TROFIN
    Location: Leibniz-Institut für Polymerforschung e.V., Dresden, Germany, within the Department of Polymer Interfaces, Dr. Frank Simon
    Period: 25.10-07.11.2021
    Theme: Short training for X-ray photoelectron spectroscopy (XPS) and solid surface electrokinetic investigations. 
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