Project: PN-III-P1-1.2-PCCDI-2017-0083
Acronym: TERADOT
Director partner PPIMC: Dr. Mariana PINTEALA
Duration: 2018 – 2020

The TERADOT consortium will implement this project with the aim of reaching its strategic objective: the consolidation of the consortium scientific and technical competencies (in particular those of the P3 partner with relaunch potential) in the field of econanotechnologies and advanced materials by supporting/ developing the existing research competences and the transferability of its research results. The TERADOT Consortium is an alliance that will devote its efforts to capitalize the potential of nanotechnologies by creating new teranostic platforms based on Carbon Dots (CDs) in order to radically change the proceedings to diagnose and treat cancer.

http://www.ch.tuiasi.ro/cercetare/proiecte/TERADOT/

Code: PN-III-P1-1.1-PD-2019-1021, Contract: PD 204/27.08.2020
Acronim: HIVFight
Project leader: Dr. Daniela Ailincai
Contract Authority: UEFISCDI
Contractor: ICMPP
Period: 01.09.2020-31.08.2022.

The project has as objective the obtaining of chitooligosaccharides based hydrogels for the co-delivery of antiviral and antifungal agents, used in both HIV and HIV associated co-infections treatment. The hydrogels obtained by the acid condensation of chitooligosaccharides with 2-formyl phenyl boronic acid will be used for the encapsulation of tenofovir antiviral drug. The hydrogels and drug delivery systems will be characterized from the structural, supramolecular and morphological points of view using different techniques. Rheological measurements will be used in order to evaluate the thixotropic behavior of the hydrogels, while their biodegradability will be monitored in vitro in the presence of lysozyme.  Last but not least, the antifungal activity and the biocompatibility of the systems will be also evaluated.  

Project: PN-III-P1-1.1-TE-2016-1180
Acronym: DynaCoPlat
Project coordinator: Dr. Lilia CLIMA
Duration: 2018 – 2020

The next level in Drug Discovery is the easy building and self-generation of multifunctional nanostructures from commercially available or “easy to prepare” units, which will further self-assemble in a complex, tunable and multifunctional materials, suitable for very specific targeted drug delivery. In this regard, DynaCoPlat project’s main objective is to create dynamic nanoplatforms for developing dynamic systems for enhanced multivalent biorecognition with applications in targeted drug delivery. Project’s subject “the development of efficient nucleic acid targeted delivery systems” addresses the thematic priorities of the National Development Plan 2014-2020 programs (PN III) and Horizon 2020 strategy. The project will adopt modern synthetic pathways for preparing dynamic nanoplatforms with self-assembly properties based on dynamic chemistry and combinatorial methodology. The simplicity of the synthetic constitutional strategy using accessible and simple building blocks for facile self-generated nanoplatforms, presenting synergistic DNA and cell membrane affinities, can be considered as a valuable path toward the systematic discovery of active delivery systems. An important issue we aim to address is establishing a methodology for labelling of nanoplatforms with targeting molecules and achieve successful targeting property via introduction of selective cellular markers, thus increasing the efficacy and reducing the overall toxicity of therapeutic agents. On the other side, the STRATEGIC OBJECTIVE of DynaCoPlat project is the formation and consolidation of a young multidisciplinary team of researchers with complementary knowledge and experience, able to increase their scientific visibility and integration into scientific environment by publishing the results in high impact journals and application to competitions within the national and European Framework (H2020, Era-Net, Euronanomed, etc.).

http://www.intelcentru.ro/DynaCoPlat/home

Project: PN-III-76PCCDI/2018
Acronym: ECOTECH-GMP
Responsible partner (ICMPP): Dr. Maria Cazacu
Duration: 2018-2020
Buget: 800000 Lei

Autocatalysts are used to convert vehicle exhaust (carbon monoxide, nitrogen oxides, hydrocarbons, etc.) into less harmful products, such as: carbon dioxide and nitrogen. Platinum group metals (PGMs) are the active component in autocatalysts and consequently the auto industry is the largest PGM consumer. Limited PGM resources demands recycling to support an expanding auto market. Traditional recycling methods are using high temperatures and highly oxidative agents (e.g. aqua regia) making them large energy consumers and environmental pollutants. As a result, there is a need to develop alternative ways to recycle PGMs with a significant decrease in energy consumption and a reduced impact on the environment. ECOTECH-GMP project at hand draws from the knowledge, skills and competences of top leading Romanian research institutions in materials science, physics, chemistry and engineering for creating the know-how to develop the eco-technologies required to recycle PGM with zero emissions. There is currently no such technology available in the world. Four sub-projects are proposed to solve the issue of PGM eco-recycling, encompassing electrochemistry, coordination chemistry, hydrodynamics and bioelectrochemistry. The sub-projects are intertwined and function in synergy to deliver several solutions to the issue at hand. The potential of this project is mesmerizing for any interested company: small initial capital, low energy consumption and high throughput. The benefits for the society at large are thrilling: improved public health because of decreased toxic pollutants (chlorides, nitrates, nitrides, etc.) and creating new jobs owing to the potential of this technology to transform into an industry.

http://www.3nanosae.org/ecotech-gmp-en/

Project: Research agreement no. 5289/09.08.2019 – CORTHOTEC LIMITED, London, UK
Acronym: CORTHOTEC
Project coordinator: Dr. Mariana PINTEALA
Duration: 2019 – 2020

Code: PN-III-P1-1.1-PD-2019-1182, Contract: PD 197/27.08.2020
Acronim: BioDrugSyst
Project leader: Dr. Craciun Anda-Mihaela
Contract Authority: UEFISCDI
Contractor: ICMPP
Period: 01.09.2020-31.08.2022.

The aim of the project is to obtain chitosan-based formulations for controlled delivery of 5-fluorouracil, designed for local cancer therapy. The hydrogels obtained by the acid condensation of monoaldehyde (P5P) with chitosan will be used as matrices for preparing injectable formulations, by in situ encapsulation of 5-fluorouracil, an anticancer drug. The obtained hydrogels and formulations will be characterized from structural, supramolecular and morphological points of view using adequate equipment. Thixotropic behavior will be monitored by rheological measurements. Also, in vitro studies of enzymatic degradability, biocompatibility, anticancer activity and drug release will be performed. In vivo biocompatibility tests will be achieved by collaboration with “Gr. T. Popa” University.

Code: PN-III-P1-1.1-TE-2019-0639, Contract: TE 89/03.09.2020
Acronim: InElPHoPRo
Project leader: Dr. Diana Serbezeanu
Contract Authority: UEFISCDI
Contractor: ICMPP
Period: 15.09.2020-14.09.2022.

The main objective of the proposed project is to design new flame retarded micro- and nano- fibrous membranes based on phosphorus-containing polymer, by electrospinning process. These membranes are intended to be integrated into fireman protection equipment. Phosphorus-containing polymers bearing P atom both in the main chain and/or the side chain will be synthesized by specific methods and then characterized by different techniques. The polymers prepared in the first step of the project will then be processed by solution electrospinning, with the aim to obtain phosphorus-containing membrane with improved characteristics. The electrospinning process parameters will be optimized in order to obtain membranes with “ideal fabric properties”. The obtained micro and nano- fibrous architectures will be characterized from morphological and functional point of view. Innovative fundamental approaches will be applied to design phosphorous-containing membrane having high air permeability (AP), high water vapor transport (WVTR) properties as well as high hydrostatic resistance (HR), as a class of new materials with superior properties regarding the physiological comfort, recommended for development of improved fireman protective clothes.

Project:                                    PN-III-P1-1.2-PCCDI-2017-0428

Acronym:                                  NAPOLI19

Subproject responsible:            Dr. Tinca BURUIANĂ

Members in Project 2 (PC2): Eco-friendly nanostructured hybrid materials for surface protection against deterioration caused by microorganism and pollutants

Project 2 aims to produce smart coating materials that have advanced protection properties against the development of biofilms and deposit on surfaces such as stone, paper and metal. Metallic and/or inorganic nanoparticles coatings will be synthetized by sol–gel process using supercritical CO₂, to achieve a minimal energy consumption and a manufacturing process with a low degree of pollution. Predictive models will be developed for antifungal and antibacterial properties, depending on the nature of nanoparticles that are included in the hybrid matrix. A series of tests will be carried out on the materials obtained, in order to validate biofilm prediction models with high biodegradability, under various environmental conditions.

Members in Project 3 (PC3): Biomaterials from aliphatic polyesters and micro- and nano-cellulosic modifiers for short-life and disposable products

This is a complex, multidisciplinary and innovative project, which aims to develop a new material, a bionanocomposite and a new synthesis method that can be easily scaled up. The biomaterial obtained within this project is intended for food or drugs packs, single-use medical instruments, medical sample storage containers, short-life or disposable products in large quantities that are difficult or impossible to recover. This project aims to replace petroleum-based polymers with recyclable polymers from renewable resources, to reduce the pollution caused by using plastic packaging.

https://icechim-rezultate.ro/proiect.php?id=36&lang=en

Project: POC F; 142/10.10.2016
Acronym: InoMatPol
Project coordinator: Dr. Narcisa Laura MARANGOCI
Duration: 2016 - 2019

Obiectivul general al proiectului InoMatPol consta in cresterea capacitatii, calitatii si eficientei activitatii CDI din ICMPP prin deschiderea de noi directii de cercetare si diversificarea gamei de servicii de cercetare orientate in special catre industrie – conform cerintelor de inovare ale agentilor economici din cadrul structurilor de tip cluster, in scopul stimularii competitivitatii cercetarii stintifice romanesti la nivel european si a competitivitatii economice nationale/regionale ale Institutului si ale actorilor economici in domeniul de specializare inteligenta eco-nano-tehnologii si materiale avansate.

http://http://inomatpol.icmpp.ro/

Project: PN-III-P1-1.2-PCCDI-2017-0245, Contract 26PCCDI/1.03.2018
Acronym: SUSTENVPRO
Director partner PPIMC: Dr. Marcela MIHAI
Project Component 2 (PC2): Efficiency of water treatment processes and development of innovative materials for the elimination of priority pollutants
Duration: 2018 - 2020

The objective of PC2 is to improve some technologies in advanced drinking water treatment, objective that at European level represents a challenge for drinking water suppliers. Therefore, during the project, innovative polymeric materials or composites will be designed, with properties (porosity, shape, size, sorption capacity, selectivity) adapted to the characteristics of the treated waters (types and concentrations of pollutants), with high efficiency for eliminating priorities model pollutants studied in the SUSTENVPRO project.

http://sustenvpro.dimm.tuiasi.ro/

Project: PN-III-P1-1.2-PCCDI-2017-0697
Acronym: INTERA
Project Component 4 (PC4) coordinator: Dr. Mariana PINTEALA
PC4: Polymeric conjugates for efficient induction of expression of genes of interest with applicability in cell therapy
Duration: 2018 – 2020

The complex project INTERA aims to develop innovative therapeutic methods to ameliorate the pathological progression by reducing the inflammatory process. The multidisciplinary studies proposed by INTERA can create and define new nano- or micro-medical devices usable for smart and innovative anti-inflammatory therapies. INTERA includes 4 projects: (1) Encapsulation of genetically manipulated eukaryotic cells for controlled release of pharmacologically active products; (2) Development of a 3D platform designed for pre-clinical drug testing composed of cells incorporated into three-dimensional bio-matrices; (3) Intelligent nanobioparticles designed for specific targeting  of bioactive compounds to pathological sites to reduce (treat) vascular inflammation. (4) Polymeric conjugates to induce efficiently  the expression of genes of interest with applicability in cellular therapy.

http://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/intera.html

Project:                                PN-III P1-1.2-PCCDI-2017-0697
Acronym:                              INTERA
Responsible partner (ICMPP): Dr. Gheorghe Fundueanu
Duration:                              2018-2020
Buget:                                  1,380,000 lei

    The INTERA complex project aims to develop innovative therapeutic methods that, by reducing the inflammatory process, will improve the pathological processes. INTERA includes multidisciplinary studies that only together can create and define new medical nano- or micro-devices that can be used for intelligent and innovative anti-inflammatory therapies. INTERA includes 4 projects: (1) Encapsulation of genetically manipulated eukaryotic cells for the controlled release of some pharmacologically active products (2) Creating a 3D platform designed for pre-clinical drug testing consisting of cells incorporated into three-dimensional bio-matrices; (3) Intelligent nanobioparticles designed for vectoring bioactive compounds to pathological sites for the therapy of vascular inflammation (4) Polymer conjugates for the efficient induction of expression of genes of interest with applicability in cell therapy. The consortium consists of 4 partner research units - two institutes of the Romanian Academy (IBPCNS, ICMPP), a university (UPB) and a national CD institute (INCDFM) with good territorial coverage (Bucharest-Ilfov-Iași).

http://www.icbp.ro/static/en/en-networking_grants-grants-national_grants/intera.html

Project: PN-III-P4-ID-PCCF-2016-0050
Acronym: 5D-nanoP
Project coordinator: Prof. Aatto LAAKSONEN
Duration: 2018 – 2022

 Mimicking of the living matter mechanism of cooperation by complementarity represents one of the most challenging tasks of supramolecular chemistry. The momentary solution consists in using particularly designed molecular unimers, endowed with the necessary amount of chemical information.

The 5D-nanoP project is dedicated to interfacing the fundamental research area of constitutional dynamic chemistry with the practical approaches of medicinal chemistry and biomedical applications. In the spirit of a metaphor of Jean-Marie Lehn (Nobel Prize in Chemistry, 1987), the project aims to materialize the concept of 5D chemistry in designing, synthesizing, characterizing, and using molecules with conditional affinity, to build versatile supramolecular nanoplatforms able to vectorize compounds of pharmaceutical or biochemical relevance, all of them involved in physiologic and pathologic processes at cell- and tissue-level.

http://www.intelcentru.ro/5D-nanoP/

Project: PN-III-P4-ID PCCF-2016-0050
Acronym: 5D-nanoP
Responsible partner (P2): Dr. Ioan Cianga
Duration: 2018-2022
Buget: 945,000 lei

The 5D-nanoP project aims to interface the fundamental scientific field of constitutional dynamic chemistry with the practical approaches of medical chemistry and biomedical applications. In the spirit of the metaphor launched by Jean-Marie Lehn (Nobel Prize for Chemistry, 1987), the project proposes to materialize the concept of 5D chemistry by designing, synthesizing, characterizing and using molecules with conditioned affinity, for the development of supramolecular nanoplatforms, useful as pharmacological and genetic vectors implicated in physiological or pathological processes at the cellular and tissue level.

http://www.intelcentru.ro/5D-nanoP/ro/

Project:                                     PN-III-P4-ID PCCF-2016-0050
Acronym:                                   5D-nanoP
Responsible partner (ICMPP-P3): Dr. Gheorghe Fundueanu
Duration:                                   2018-2022
Buget:                                       945,000 lei

    The 5D-nanoP project aims to interface the fundamental scientific field of constitutional dynamic chemistry with the practical approaches of medical chemistry and biomedical applications. In the spirit of the metaphor launched by Jean-Marie Lehn (Nobel Prize for Chemistry, 1987), the project proposes to materialize the concept of 5D chemistry by designing, synthesizing, characterizing and using molecules with conditioned affinity, for the development of supramolecular nanoplatforms, useful as pharmacological and genetic vectors implicated in physiological or pathological processes at the cellular and tissue level.

http://www.intelcentru.ro/5D-nanoP/ro/

Project: PN-III-P4-ID PCCF-2016-0050
Acronym: 5D-nanoP
Responsible partner (ICMPP – P4): Dr. Maria Cazacu
Duration: 2018-2022
Buget: 945,000 Lei

The 5D-nanoP project aims to interface the fundamental scientific field of constitutional dynamic chemistry with the practical approaches of medical chemistry and biomedical applications. In the spirit of the metaphor launched by Jean-Marie Lehn (Nobel Prize for Chemistry, 1987), the project proposes to materialize the concept of  5D chemistry by designing, synthesizing, characterizing and using molecules with conditioned affinity, for the development of supramolecular nanoplatforms, useful as pharmacological and genetic vectors implicated in physiological or pathological processes at the cellular and tissue level.

http://www.intelcentru.ro/5D-nanoP/ro/

Project: POC E; P_37_707/31.08.2016
Acronym: POCPOLIG
Project coordinator: Dr. Vasile LOZAN / Project manager: Dr. Narcisa Laura MARANGOCI
Duration: 2016 - 2020

The objective of the project is to increase the capacity and quality of the research and innovation development activity by attracting specialists with advanced skills, opening a new research direction in the field of metal-organic networks (MOF) and diversifying the range of research services and transferring them to industrial partners, in order to stimulate the competitiveness of the Romanian scientific research at European level and of the national/regional economic competitiveness of the Institute and of the economic actors in the field of intelligent specialization of eco-nano-technologies and advanced materials.

http://pocpolig.icmpp.ro/

Code: PN-III-P1-1.1-MCT-2019-0066; Contract no. 7/8.08.2019
Project number: No. 525/21.01.2019
Project leader (Romania): I. Sava
Period: 2019-2020.

Bilateral Project between Shibaura Institute of Technology, Tokyo  - Japan and “Petru Poni” Institute of Macromolecular Chemistry, Iasi

Project: PN-III-25 PCCDI/2018
Acronym: ROFCC
Responsible partner (ICMPP): Dr. Valeria Harabagiu
Duration: 2018-2020
Buget: 709582 Lei

Fuel cell is unanimously considered the core of the hydrogen –based energy revolution. It promises to impact environmental and economic issues facing the world every day. Modern lifestyles, high prices for diminishing supplies of fossil fuels, and the environmental impact of energy production have all made alternative power generation technology like fuel cells a necessity. The proposed project is looking to find bridges between several scientific disciplines in order to reduce the main technological barriers which hinder the commercialization of PEM fuel cell at large scale.
Electrochemical energy conversion involves complex developments of materials: due to the close link between electricity flow and corrosion processes, morphological changes, building of resistive layers and exhaustion of catalytically active components, material development for enhanced lifetimes becomes the major challenge in fuel cell basic research and development. At the same time, the topics of low-cost materials and processing have to be additionally tackled in order to achieve acceptable market costs. Advances in the development of new catalysts, new bipolar plates, enhanced solid electrolyte are only few of the foreseen development within the project, based on joining the existing capabilities proved in other topics by the partners. The proposal covers entire range of research from applicative industrial research focused onto optimization materials/processes until experimental development for testing and validation of the production technology including a comprehensive cost analysis on life time.
By connecting the capabilities of several research partners in complementary topics, from physics, chemistry (especially electrochemistry but not only), mechanics, processes automation, etc. the project will bring the fuel cell development technology close to the market and ready to fulfill the requirements of the new hydrogen based chain energy system.

https://www.icsi.ro/rofcc-english-version/