Results delivered on first stage (2020):

-synthesis of three types of glycopeptide based on leucine, lysine and cysteine by ring-opening polymerization using a chitosan derivative (maleil-chitosan) as initiator.

Dissemination on first stage (2020):

Scientific results – Research Articles:

1. Alina Gabriela Rusu, Aurica P. Chiriac, Loredana Elena Nita, Irina Rosca, Daniela Rusu, Iordana Neamtu. Self-Assembled Nanocarriers Based on Modified Chitosan for Biomedical Applications: Preparation and Characterization. Polymers 2020, 12 (11), 2593, IF 3.426.

Results delivered on second stage (2021):

• Preparation of functionalized magnetic nanoparticles  and conjugated with with catalytic enzymes (glucose oxidase) and determination of optimal conditions for increased stability in simulated biological environments and enzymatic activity;
• Obtaining polymersomes loaded with enzyme-conjugated magnetic nanoparticles by nanoprecipitation; 

Dissemination on second stage (2021):

Scientific results – Research Articles:

1.Alina Gabriela Rusu, Aurica P. Chiriac, Loredana Elena Nita, Alina Ghilan, Daniela Rusu, Natalia Simionescu, Liliana Mititelu Tartau. Nanostructured hyaluronic acid-based hydrogels encapsulating synthetic/ natural hybrid nanogels as promising wound dressings. Biochemical Engineering Journal, IF 3.978 (under review).

Scientific results – International Conferences:

1. Synthesis and characterization of maleoyl-chitosan/polypeptide bioconjugate; Alina Gabriela Rusu, Aurica P. Chiriac, Loredana Elena Nita; 7th International Polysaccharide Conference (EPNOE 2021), Nantes, France, 11-15 October 2021 (poster).

2.Enzymatic crosslinked hydrogels based on gelatin loaded with maleoyl-chitosan/poly (aspartic acid) nanocarriers as potential therapeutic scaffolds for tissue engineering, Alina Gabriela Rusu, Aurica P. Chiriac, Loredana Elena Nita, 31st Annual Conference of the European Society for Biomaterials (ESB 2021), Porto, Portugal, fully virtual, 5-9th September 2021 (poster).

Results delivered on second stage (2022):

• Preparation and characterization of magnetic polymersomes based on glycopeptides (MAC-pLeu (maleoyl-chitosan-g-poli(leucine)), MAC-p(Leu-co-CBZ-Lys)1:0.5 (maleoyl-chitosan-g-poli(leucine-co-CBZ-lysine) and MAC-p(Leu-co-CBZ-Lys)1:0.75) and GOx-coated magnetic particles;
• Studies regarding the therapeutic effect of the glycopeptide-based micro/nanomotors after loading with two anti-tumoral drugs – dacarbazine (DTIC) and vinblastine (VCL) - for melanoma therapy.

Dissemination on second stage (2022):

Scientific results – Research Articles:

1. Alina Gabriela Rusu, Aurica P Chiriac, Loredana Elena Nita, Vera Balan, Alexandru Mihail Serban, Alexandra Croitoriu, Synthesis and Comparative Studies of Glucose Oxidase Immobilized on Fe₃O₄ Magnetic Nanoparticles Using Different Coupling Agents, Nanomaterials 2022, 14(12), 2445, IF = 5.719.

Scientific results – International Conferences:

1. Synthesis and characterization of dacarbazine loaded chitosan polymersomes, Alina Gabriela Rusu, Aurica P. Chiriac, Loredana Elena Nita, Vera Balan, Polymers 2022 - New Trends in Polymers Science: Health of the Planet, Health of the People”, Turin, Italia, 24-27 May 2022 (poster).