Funding programme: HUMAN RESOURCES

Subprogram: Postdoctoral project

Project title: Injectable chitosan based hydrogels acting as biocompatible and biodegradable matrices for 5-fluorouracil formulations with local anticancer application

Acronym: BioDrugSyst

Project code: PN-III-P1-1.1-PD-2019-1182

Contract Authority: Executive Agency for Higher Education, Research, Development and Innovation Funding                 

Contractor: “Petru Poni” Institute of Macromolecular Chemistry, Iasi

Project director: Dr. Anda Mihaela Craciun

Mentor: Dr. Luminita Marin              

Project period: 01.09.2020– 31.08.2022

Budget: 246 950 lei

Abstract  

         The aim of the project is to obtain chitosan-based formulations for controlled delivery of 5-fluorouracil, designed for local cancer therapy. The hydrogels obtained by the acid condensation of monoaldehyde (P5P) with chitosan will be used as matrices for preparing injectable formulations, by in situ encapsulation of 5-fluorouracil, an anticancer drug. The obtained hydrogels and formulations will be characterized from structural, supramolecular and morphological points of view using adequate equipment. Thixotropic behavior will be monitored by rheological measurements. Also, in vitro studies of enzymatic degradability, biocompatibility, anticancer activity and drug release will be performed. In vivo biocompatibility tests will be achieved by collaboration with “Gr. T. Popa” University.