The main expected results of the project strongly rely on identifying the two key components – the polymers with intrinsic capacity of gelling and – LMWGs with potential for supramolecular assembly. The project results, beside highlighting the effectiveness of the biohybrid structures will contribute to: - enhancing of research development innovation (RDI); - performance of the system; developing of RDI system resources by increasing of the research results capacities; expanding of international cooperation by offering for tests new bioactivecompounds and a new hybrid polymer/peptide hydrogel system for multidimensional cultures applications.
The project starts from a concept formulated by technology (TRL 2) and will materialize in the validated technology of the laboratory for new bioactive polymer conjugate system (TRL 4).

Dissemination

Articles:

1. Alginate enriched with phytic acid for hydrogels preparation; L. E. Nita, A. P. Chiriac, A. Ghilan, A.G. Rusu, N. Tudorachi, D. Timpu; International Journal of Biological Macromolecules 181, 561 (2021). IF=6.953

2. Alginate enriched with phytic acid for hydrogels preparation. Therapeutic applications, LE Nita, AP Chiriac, A Ghilan, AG Rusu, D Pamfil, I Rosca, L Mititelu-Tartau, International Journal of Biological Macromolecules, 189, 335 (2021). IF=6.953

3. Co-assembled peptides hierarchically oriented for supramolecular gel formation; A. Croitoriu, L.E. Nita, A. G. Rusu, F. Doroftei, L. Verestiuc Rev. Roum. Chim., 65(5), 449 (2021). IF=0.418

4. New physical pydrogels pased on po-assembling of FMOC–amino acids, A. Croitoriu , L. E. Nita, A. P. Chiriac , A. G. Rusu, M. Bercea, Gels  7, 208 (2021). IF=4.702

5. New hydrogel hetwork based on alginate and a spiroaceta copolymer, A. E. Sandu, L. E. Nita, A. P. Chiriac, N Tudorachi, A. G. Rusu, D Pamfil, Gels, 7, 241 (2021). IF=4.702

6.  Synthesis of poly(Ethylene brassylate-co-squaric acid) as potential essential oil Carrier, A. P. Chiriac, A. G. Rusu, L. E. Nita, A.-M. Macsim, N. Tudorachi, I. Rosca, I. Stoica, D. Timpu, M. Aflori, F. Doroftei; Pharmaceutics, 13, 477 (2021). IF=6.07

7. Polymeric carriers designed for encapsulation of essential oils with biological activity, A. P. Chiriac, A. G. Rusu, L. E. Nita, V. M. Chiriac, I. Neamtu, A. Sandu; Pharmaceutics 13, 631 (2021). IF=6.07

Patent request: A/00465/05.08.2021: PROCEDEU DE PREPARARE A UNUI GEL AUTOASAMBLAT PE BAZA DE PEPTIDE, Autori : LE Nita, AP Chiriac, AG Rusu, A Croitoru, MA Serban, I Neamtu, C Munteanu. 

Paper published in ISI Conference Procedeeng: 

1.         A.Raicu, I.Cobzariu, A.L.Vasilache, C.A. Peptu, M. Butnaru, L.Verestiuc, New Hydrogels Based on Methacrylated Collagen and Hyaluronic Acid for Soft Tissue Engineering (Invited), 5th INTERNATIONAL CONFERENCE on Nanotechnologies and Biomedical Engineering, November 3-5, 2021, Chisinau, Republic of Moldova

2.         A. Luca, T.R. Craescu, L. Verestiuc,  M. Butnaru, Mimicking In Vivo Tissue Microenvironment for In Vitro Testing –Hydrogels for Cell Encapsulation, 5th INTERNATIONAL CONFERENCE on Nanotechnologies and Biomedical Engineering, November 3-5, 2021, Chisinau, Republic of Moldova

3.         Roxana Donea, Isabella Cobzariu, Maria Butnaru and Liliana Verestiuc, , IEEE E-HEALTH AND BIOENGINEERING CONFERENCE - EHB 2021, 9-th edition, Iași, Romania, November 18-19, 2021

4. Supramolecular gels based on amino acids, A. Croitoriu, L. E. Niță, A. G. Rusu, A. Cimponeriu, A. Chiriac, IEEE International Conference on e-Health and Bioengineering EHB 2021 - 9-th Edition, 18-19 November 2021, Iasi - WEB CONFERENCE – Romania 

5. New polymeric particles loaded with sea buckthorn essential oil, A. E. Sandu, A. Chiriac, A. G.Rusu, A. M. Serban, L. E. Niță, E. Gille, IEEE International Conference on e-Health and Bioengineering EHB 2021 - 9-th Edition, 18-19 November 2021, Iasi - WEB CONFERENCE - Romania

Paper published in Conference Procedeeng: 

Isabella Cobzariu, Maria Bercea, Catalina Anisoara Peptu, Maria Butnaru, Liliana Verestiuc, 3D Bioprinted scaffolds based on functionalised gelatin and PEGDA for soft tissue engineering, Proceedings International Conference Progress in Organic and Macromolecular Compounds, International Conference Progress in Organic and Macromolecular Compounds, 28th Edition, Iasi | Romania | October 7 - 9, 2021, ISSN 2810 – 2347,pp 47-48

Oral presentations

Supramolecular gels based on amino acids, A. Croitoriu, L. E. Niță, A. G. Rusu, A. Cimponeriu, A. Chiriac, IEEE International Conference on e-Health and Bioengineering EHB 2021 - 9-th Edition, 18-19 November 2021, Iasi - WEB CONFERENCE – Romania 
New polymeric particles loaded with sea buckthorn essential oil, A. E. Sandu, A. Chiriac, A. G.Rusu, A. M. Serban, L. E. Niță, E. Gille, IEEE International Conference on e-Health and Bioengineering EHB 2021 - 9-th Edition, 18-19 November 2021, Iasi - WEB CONFERENCE - Romania
Poster presentations

New gels preparation based on peptide-peptide co-assembly, Alexandra Croitoriu, Loredan Elena Nita, Alexandru Serban, Alina Gabriela Rusu, 31st Annual Conference of the European Society for Biomaterials (ESB 2021), online, 5-9 Septembrie 2021