SUMMARY stage I:
- Chemical functionalization protocols for pullulan were developed and optimized, using selective oxidation methods.
- Depending on the selectivity of the oxidizing agent (TEMPO – for the oxidation of primary hydroxyl groups, NaIO4 – for the oxidation of secondary hydroxyl groups, TEMPO in combination with NaIO4 – for the simultaneous or two-step oxidation of primary and secondary hydroxyl groups) carboxylic, aldehyde and/or aldehyde and carboxylic groups were introduced into the pullulan structure, groups that will act as active sites for the preparation of hydrogels.
- The structure of the oxidized materials was confirmed by FTIR and NMR spectroscopy.
- All indicators set out in the "project implementation plan" were achieved: 1 published paper (0 proposals), creation of the project website.
Project impact:
The activities carried out during Stage I contributed significantly to expanding knowledge in the field of polysaccharide functionalization, through the development and optimization of novel and selective oxidation protocols. The results obtained provide good control over the introduction of functional groups. These contributions will strengthen the research capabilities of the team, and the scientific impact will be reflected through the dissemination of results in scientific publications, participation in conferences, and the initiation of interdisciplinary collaborations.
From a socio-economic perspective, the proposed selective protocols are efficient and cost-effective, relying on reaction conditions that are suitable for scale-up and adaptable to a wide range of polysaccharides. By promoting the valorization of renewable resources and the gradual replacement of petroleum-derived materials, the project supports key directions related to the circular economy and sustainability.
The project also involves the advanced training of early-career researchers (one PhD student and three postdoctoral researchers), who will acquire skills in synthesis, characterization, and data interpretation. This will support their career development, increase the competitiveness of the research team, and enhance the international visibility of the host institution through publishable results and participation in relevant scientific events. |
