OBJECTIVES of IntelDots project:

The IntelDots project’s general objective is to attract high-level personnel from abroad, and launching a new research area at IntelCentru, an ICMPP department, by implementing a project related to the field of intelligent systems for cancer diagnosis and treatment, based on MF Cdots, and therefore to support and increase the quality and capacity of the research, development, and innovation (RDI) activity.

A set of specific objectives (SO) are considered in order to attempt this ambitious goal:

SO1: Development and advancement of fundamental scientific research in Romania by creation of a strong research group under the supervision of a top-level specialist, and establishment of a new RDI area at IntelCentru.

SO2: Encouraging the training of competent human resources and the creation of interdisciplinary research group under the supervision of a high-level specialist.

SO3: Increasing the number of publications with high international impact and successful participation in the competitions of the H EU framework program.

The IntelDots project is multidisciplinary per se (implying chemistry, cancer biology, engineering and computational chemistry), and has a major objective to gain an increased knowledge and expertise in designing and producing nano-tools for cancer diagnosis and treatment, addressed to EU Cancer Mission Recommendations.

Besides its specific objectives, IntelDots project intends to build up a team of high expertise in understanding and providing solutions for both diagnostic and treatment in personalized medicine.
According to the SOs, the IntelDots work program also includes a set of specific research objectives (RO):

RO1: Intelligent Systems based on peptide, cyclodextrin, and Mn@CND with anticancer activity.
Obtaining and testing manganese-dopped carbon dots from imidic precursors, usable as nanoplatforms for cancer diagnosis and treatment. Development of intelligent systems based on carbon dot functionalized with cyclodextrins, which can form inclusion complexes with hydrophobic moiety connected to particular cell targeting peptides. In vitro/in vivo testing and magnetic resonance (MR) investigations of the selected intelligent systems.

RO2: Liposomal formulations containing hemp oil nanoemulssions and Mn@CND.
Development of liposomes containing hemp oil nanoemulssions and Mn@CND. In vitro/in vivo testing and MR investigations of the selected intelligent systems.

RO3: Multiscale Modelling of the Intelligent Systems
Characterization at the atomistic level of the intelligent systems and the interactions between components; development of mathematical and pharmacokinetic models for passive and active diffusion of drugs through the skin and release of the drugs to blood flow pharmacokinetics.