EcoDesign Lab

The latest projects and research

• Project title: Chitooligosaccharides based hydrogels for the co-delivery of antiviral and antifungal agents - HIVFight (postdoctoral project )
  This project aims to synthesize chitooligosaccharides based drug delivery systems, able to co-deliver and release in a sustained manner antifungal and antiviral agents.
  Project director: Dr. Daniela Ailincai
  Mentor: Dr. Luminita Marin
  Project period: 01.09.2020– 31.08.2022
  


• Project title: Eco-nanomaterials based on chitosan for applications of contemporary interes - ECO-MAT (exploratory research projects )
  The goal of the project is to develop new ecological sustainable chitosan-based nanofibers by ecological electrospinning method in view of application in healthcare and environment protection. The central idea is to use quaternary salts of chitosan as co-spinning agent of chitosan to prepare a library of chitosan/quaternary salts of chitosan nanofibers.
  Project Leader: Dr. Luminita Marin
  


• Project title: Injectable chitosan based hydrogels acting as biocompatible and biodegradable matrices for 5-fluorouracil formulations with local anticancer application - BioDrugSyst (postdoctoral project )
  The aim of the project is to obtain chitosan-based formulations for controlled delivery of 5-fluorouracil, designed for local cancer therapy. The hydrogels obtained by the acid condensation of monoaldehyde (P5P) with chitosan will be used as matrices for preparing injectable formulations, by in situ encapsulation of 5-fluorouracil, an anticancer drug.
  Project director: Dr. Anda Mihaela Craciun
  Mentor: Dr. Luminita Marin
  Project period: 01.09.2020– 31.08.2022
  


• Project title: Resorbable Bandage with "On Demand" Norfloxacin Release for the Healing of Burn Wounds - BurnHeal (demonstration experimental project)
  The present project intend to provide a marketable product for burn wound healing. The product is designed in the form of a non-woven fiber bandage made of biodegradable chitosan, and is expected to promote the scar-free healing, without trauma. Therefore, the final product is expected to ensure the exudate drainage and to act as a barrier against bacterial and fungal infections.
  Project Leader: Dr. Luminita Marin
  


• Project title: H2020-MSCA-RISE-2019: Smart Wound Monitoring Restorative Dressings - SWORD (Horizon2020)
  The project aims to combine the expertise and resources of four academic groups working at the frontiers of material research and two SMEs, one engaged in producing commercial medical materials as well as having own research capacities.
  The Consortium plans to develop wound dressings which can be rated as a radical innovation in the area of chronic wound care. Our efforts will concentrate on the design of a new product which will combine diagnostic and therapeutic actions and facilitate wound healing, while at the same time minimize treatment costs and optimize wound management thus positively influencing the wellbeing of the patients.
  Project Leader: Dr. Luminita Marin

Some of the newest papers published in ISI journals

• A. Ansiei, I. Rosca, A.-I, Sandu, A.Bele, X. Cheng, L. Marin, Imination of Microporous Chitosan Fibers—A Route to Biomaterials with “On Demand” Antimicrobial Activity and Biodegradation for Wound Dressings, Pharmaceutics, 14(1), 117, doi:10.3390/pharmaceutics14010117 (2022).


• A. Anisiei, A.-C. Bostanaru, M. Mares, L. Marin, Imination of chitosan nanofibers in heterogeneous system. Synthesis optimization and impact on the fiber morphology, Cellulose Chemistry and Technology, 55(7-8), 785-793, doi:10.35812/CelluloseChemTechnol.2021.55.65, (2021).


• Alexandru Ansiei, Florin Oancea, Luminita Marin, Electrospinning of chitosan-based nanofibers: from design to prospective applications, Reviews in Chemical Engineering, 000010151520210003, (2021).


• Ramona Lungu, Alexandru Anisiei, Irina Rosca, Andreea-Isabela Sandu, Daniela Ailincai, Luminita Marin, Double functionalization of chitosan based nanofibers towards biomaterials for wound healing, Reactive and Functional Polymers, 167, 105028, (2021).


• Anda-Mihaela Craciun, Liliana Mititelu-Tartau, Gabriela Gavril, Luminita Marin, Chitosan crosslinking with pyridoxal 5-phosphate vitamer toward biocompatible hydrogels for in vivo applications, International Journal of Biological Macromolecules, https://doi.org/10.1016/j.ijbiomac.2021.10.228, (2021).


• D. Ailincai, I. Rosca, S. Morariu, L. Mititelu Tartau, L. Marin, Iminoboronate - Chitooligosaccharides Hydrogels with strong antimicrobial activity for biomedical applications, Carbohydrate Polymers, 118727 (2021).


• Daniela Ailincai, Gabriela Gavril, Luminita Marin, Polyvinyl alcohol boric acid – A promising tool for the development of sustained release drug delivery systems, Materials Science and Engineering: C 107, 110316 (2020).


• Elena Perju, Yuri S. Ko, S. J. Dünki, Dorina M. Opris, Increased electromechanical sensitivity of polysiloxane elastomers by chemical modification with thioacetic groups, Materials and Design, 186, 108319 (2020).


• Anda Mihaela Craciun, Liliana Mititelu Tartau, Mariana Pinteala, Luminita Marin, “Nitrosalicyl-imine-chitosan hydrogels based drug delivery systems for long term sustained release in local therapy”, Journal of Colloid and Interface Science 536, 196–207 (2019).


• Daniela Ailincai, Dragos Peptanariu, Mariana Pinteala, Luminita Marin, “Dynamic constitutional chemistry towards efficient nonviral vectors”, Materials Science and Engineering: C 94, 635-646 (2019).


• Luminita Marin, Brindusa Dragoi, Niculae Olaru, Elena Perju, Adina Coroaba, Florica Doroftei, Guido Scavia, Silvia Destri, Stephania Zappia, William Porzio, “Nanoporous furfuryl-imine-chitosan fibers as a new pathway towards eco-materials for CO2 adsorption”, European Polymer Journal 120, 109214 (2019).


• Anda-Mihaela Craciun, Mihaela Luminita Barhalescu, Maricel Agop, Lacramioara Ochiuz, Theoretical modeling of long time drug release from nitrosalicyl-imine-chitosan hydrogels through multifractal logistic type laws, Computational and Mathematical Methods in Medicine, 4091464 (2019).


• Shuangyu Xiong, Luminita Marin, Lian Duan, Xinjian Cheng, “Fluorescent chitosan hydrogel for highly and selectively sensing of p-nitrophenol and 2, 4, 6-trinitrophenol” Carbohydrate Polymers 225, 115253 (2019).


• Dumitru Popovici, Andrei Diaconu, Aurelian Rotaru, Luminita Marin, “Microwave-assisted synthesis of an alternant poly(fluorene–oxadiazole). Synthesis, properties, and white light-emitting devices”, Polymers 11, 1562 (2019).


• Manuela-Maria Iftime, Vasile Cozan, Anton Airinei, Cristian Varganici, Gabriela Ailiesei, Daniel Timpu, Ion Sava, Asymmetric azomethine amines with azobenzene moieties – liquid crystalline and optical properties, Liquid Crystal, 46, 10, 1584-1594 (2019).


• Manuela Maria Iftime, Gabriela L. Ailiesei, Elena Ungureanu, Luminita Marin, “Designing chitosan based eco-friendly multifunctional soil conditioner systems with urea controlled release and water retention”, Carbohydrate Polymers 223, 115040 (2019).


• Wei Sun, Qi Sun, Qiang Zhao, Luminita Marin, Xinjian Cheng, “Fluorescent porous silica microspheres for highly and selectively detecting Hg2+ and Pb2+ ions and imaging in living cells”, ACS Omega 4, 18381-18391 (2019).