(Pyrrole-sulfonamide)collagen - an innovative active principle for targeting advanced treatment of chronic wounds
(COOL-PYRRO-GEN)


COOL
PYRRO
GEN
 

TEAM Project

Petru Poni Institute of Macromolecular Chemistry, Iași
 

Cristina Maria Al-Matarneh

Principal investigator

- organic synthesis of N-heterocycle compounds;
- advanced knowledge in structural characterization techniques FT-IR, NMR, MS and X-Ray crystallography data interpretation;
- proficiency in biological applications;
- utilization of molecular simulation techniques to study the behavior and interactions of biologically active molecules, contributing to a deeper understanding of their mechanisms and potential applications.

 
 

Mariana Pinteala
Senior Researcher

- development of biopolymer
- based materials, structure-property relationship evaluation, data analysis and interpretation.

 
 

Mihaela Silion
Researcher Member

- separation/identification methods of organic compound, drugs and biopolymers using HPLC-MS and MALDI-MS spectrometry;

 
 

Alina Nicolescu
Researcher Member

- structural studies and adaptation of pulse sequences and NMR experiments for the study of organic, organometallic, macromolecular compound as well as particular expertise in NMR studies of host-guest interactions;

 
 

Anca Petrovici
Researcher Member

- determination of antioxidant properties of active -compounds from ex vivo, in vitro and in vivo media;
- controlled release studies by HPLC-ESI-MS;

 
 

Natalia Simionescu
Postdoctoral Member

- hand-on experience in cell culture techniques and biological assessments like: in vitro biocompatibility/cytotoxicity and intracellular antioxidant activity of biological and synthetic compounds, in vitro biological evaluation of medical devices, ELISA and molecular biology;

 
 

Rafaela Vrabie
Technician Member

- master student;

 
 
Partner P1 - SC DELTAROM SRL
 
 

Ioana Cristina Marinas
Partner 1 Leader (P1)

- biochemist with expertise in development and implementation of spectrophotometric (FTIR, UV-Vis and fluorescence) and chromatographic (HPLC, HPTLC) methods for the identification and quantification of active principles, amino acids and various matrices of animal and plant origin;
- enzymatic and classical extractions and biological properties easements;
- optimization of processes/products through experimental design;

 
 

Coralia Bleotu
Researcher Member

- biologist with extensive experience in in vitro and in vivo investigation of alternative antibacterial and antiviral treatments in order to select active principles with anti-infective and immunomodulatory action;
- study of the interaction of eukaryotic cells with different types of active compounds included in natural biodegradable polymers, in order to obtain systems for stabilizing some active principles with anti-infective and anti-inflammatory activity.

 
 

Mariana Carmen Chifiriuc
Researcher Member

- experience in the in vitro assessment of the microbicidal/microbiostatic/antipathogenic activity of new compounds and the investigation of the interaction of hybrid materials with planktonic and adherent microbial cells;
- holds long-standing experience in Microbiology and Immunology focusing on the characterization of virulence and resistance features of different environmental, animal and human microbiomes, development of antimicrobial and immunomodulatory strategies, and study of infectious agent-host relationships.

 
 

Sergiu Stelian Maier
Researcher Member

- development and implementation of analytical methods (physico-chemical and biological);
- development of validation protocols for technological processes;
- evaluation of results and efficiency of stages;
analysis and mathematical modeling of non-linear time series of technological interest;
- physico-chemistry of active principles and evaluation of rheological properties;
- pharmaceutical vectors and encapsulation systems.

 
 

Marin Angheloiu
Researcher Member

- morphological and structural characterizations of macroporous surfaces.
- evaluation of rheological properties of wet collagen forms.
- material characterization through advanced microscopy techniques (SEM).

 
 

Nicolae Daniel Andreiu
Researcher Member

- specialist in monitoring technological processes for the production of collagen, verification/validation of the operating status at optimal parameters of the production equipment.

 
The project leading to this application has received funding from the Ministry of Research, Innovation and Digitization