TechMembrEID

TechMembrEID

Improved technologies for the development of electrospun polysulfonic membranes integrated in an Innovative Extracorporeal Device (EID) applicable in renal failure
Project code: PN-III-P2-2.1-PED-2021-2700
No. 579PED - 2022

Project description

Renal failure is one of the major health problems with which the current society is faced, having a negative impact on the health system due to the disease prevalence. This shortcoming requires new innovations in terms of dialysis therapies, through the approaches/strategies and therapeutic dialysis means that are cost-effective, accessible and that provide improved results for patients.
From this perspective, the project aims to develop a high-performance technology, tested and validated on a laboratory scale, which will ensure an advanced hemodialysis treatment, contributing significantly to the quality and efficiency of systems that address to the human health.

Implementation period: 28.06.2022- 28.06.2024
Budget: 598 795 lei
Project director: dr. Anca FILIMON (Coordinator - ICMPP)
E-mail: afilimon@icmpp.ro

Specific objectives

The general objective of the TechMembrEID project consists in the design and development of new bioactive electrospun membranes - bioactive fibrous membranes based on quaternized polysulfones - with improved characteristics (modeled and controlled morphology, hydrophilic/hydrophobic balance, biocompatibility), which will be used as separation media in an innovative extracorporeal device, which will be tested and validated on a laboratory scale.

  • Formulation and designing of biocompatible functionalized membranes based on quaternized polysulfone (FHM).
  • Optimizarea proprietatilor de suprafata in vederea obtinerii de membrane FHM aplicabile in procesul de dializa.
  • Designing of an innovative extracorporeal device (EID) by integrating the optimized experimental demonstrator (FHM) into a final product.
  • Evaluation of the FHM membranes functionality for medical applications and validation of laboratory technology through the specific tests.

    • Project stages

    Stage 1 (2022) - Formulation and development of bioactive functionalized fibrous membranes (FHMs) and designing of an innovative extracorporeal device (EID)

    Activity 1.1 - Establishing the optimal electrospinning conditions by optimizing the obtained rheological parameters
    Activity 1.2 - Obtaining the biocompatible fibrous composite membranes
    Activity 1.3 - Obtaining the biocompatible functionalized fibrous membranes based on quaternized polysulfone (FHMs) by incorporating antioxidants
    Activity 1.4 - Setting the Extracorporeal Innovative Device (EID)
    Activity 1.5 - The results dissemination

    Stage 2 (2023) - Optimizing the surface properties of FHMs membranes and evaluating their functionality in medical applications through integration into the EID device

    Activity 2.1 - Obtaining of functionalized biocompatible fibrous membranes based on quaternized polysulfone (FHMs) by incorporation or immersion in anticoagulant solutions
    Activity 2.2 -Controlling the hydrophobic/hydrophilic balance by studying the surface tension and hydration free energy
    Activity 2.3 - Morphological and structural characterization of the obtained FHM membranes
    Activity 2.4 - Membranes testing as biocide and establishing the inhibition mechanism against different types of bacteria
    Activity 2.5 - In vitro screening of FHM membranes for biocompatibility evaluation
    Activity 2.6 - Configuration and commissioning of the proposed innovative extracorporeal device
    Activity 2.7 - Optimizing the operating parameters of the EID device
    Activity 2.8 - Control of the dialysis process
    Activity 2.9 - The results dissemination

    Stage 3 (2024) - Validation/testing and demonstration of the functionality of the EID device with integrated FHMs membranes

    Activity 3.1 - Demonstration of the FHMs membranes functionality for medical applications
    Activity 3.2 - Evaluation of the plasma level of reactive oxygen species
    Activity 3.3 - Hemocompatibility tests
    Activity 3.4 - The results dissemination

    Activity Reports

  • Scientific and Technical Report 2022
  • Scientific and Technical Report 2023
  • Scientific and Technical Report 2024

    • Dissemination

    Stage 1 (2022)

    Estimated results::

  • obtaining of several types of composite solutions based on functionalized polysulfone (accomplished) (accomplished)
  • achievement of the electrospun composite membranes (accomplished)
  • achievement of the biocompatible functionalized fibrous membranes based on quaternized polysulfone (FHMs) (accomplished)
  • 2 participations at international/national conferences (accomplished)


    • Obtained results:


    Papers published in ISI journals:

    1. D. Serbezeanu, C. Hamciuc, T.Vlad-Bubulac, M.D. Onofrei, A. Bargan, D. Rusu, D.M. Suflet, G. Lisa, Electrospun nanofibers based on polymer blends with tunable high-performance properties for innovative fire-resistant materials, Polymers (in evaluation)

    Participations at conferences:

    1. A.M. Dobos, M.D. Onofrei, D. Serbezeanu, L. Lupa, A. Filimon, Polysulfone-based composite fibrous membranes: Influence of the solution parameters on the electrospinning process, New Trends and Strategies in the Chemistry of Advanced Materials with Relevance in Biological Systems, Technique and Environmental Protection, Timisoara, Romania, 20-21 October 2022 (poster)
    2. A. Filimon, D. Serbezeanu, A.M. Dobos, M.D. Onofrei, D. Rusu, L. Lupa, Role of the solvent in electrospinning process of fibrous materials based on polysulfone, 28th International Symposium on Analytical and Environmental Problems, Szeged, Hungary, 14-15 November 2022 (poster)



    Stage 2 (2023)

    Estimated results:

  • technical-scientific report on the optimal operating parameters of the EID device (accomplished)
  • 2 ISI scientific papers sent for publication (accomplished)
  • 3 participations at international/national conferences (accomplished)
  • 1 patent application (in progress)



    • Obtained results:


    Papers published in ISI journals:

    1. D. Serbezeanu, C. Hamciuc, T.Vlad-Bubulac, M.D. Onofrei, A. Bargan, D. Rusu, D.M. Suflet, G. Lisa, Electrospun nanofibers based on polymer blends with tunable high-performance properties for innovative fire-resistant materials, Polymers, 14, 2022, 5501. (published 12.2022)
    2. A. Filimon, M. D. Onofrei, A. Bargan, I. Stoica, S. Dunca, Bioactive materials based on hydroxypropyl methylcellulose and silver nanoparticles: Structural-morphological characterization and antimicrobial testing, Polymers 15, 2023 1625.
    3. O. Dumbrava, A. Filimon, L. Marin, Tailoring properties and applications of polysulfone membranes by chemical modification: Structure-properties-applications relationship, Eur Polym J, 196, 2023, 112316.
    4. A. Filimon, D. Serbezeanu, A.M. Dobos, M.D. Onofrei, A. Bargan, O. Dumbrava, D. Rusu, C.M. Rimbu, Nanofibers membranes based on polysulfones with properties tailored for applications in biomedical field, Composite Structures (under review)


    Participations at conferences:

    1. A. Filimon, L. Lupa, D. Serbezeanu, A. M. Dobos, O. Dumbrava, Improved technologies for the development of electrospun polysulfone membranes integrated in an extracorporeal device applicable in renal failure, 27th International Exhibition of Inventions "INVENTICA 2023", Iasi, Romania, 21-23 June 2023
    2. O. Dumbrava, A. Filimon, L. Marin, Theoretical and experimental approaches applied in the formulation of polysulfone based materials: Solubility parameter and intrinsic viscosity, 21st International Balkan Workshop on Applied Physics and Materials Science-IBWAP, Constanta, Romania, 11-14 July 2023
    3. A. Filimon, D. Serbezeanu, M. Onofrei, O. Dumbrava, D. Rusu, E. Milos, L. Lupa, Processing of quaternized polysulfone/cellulose acetate phthalate/polyvinylidene fluoride solutions by electrospinning to obtain bioactive fibrous membranes, 17th International Conference of Physical Chemistry-ROMPHYSCHEM, Bucuresti, Romania, 25-27 September 2023
    4. O. Dumbrava, D. Serbezeanu, I. Stoica, A. Bargan, A. Filimon, New insights in the design of materials based on polysulfones with potential applications in biomedical field: structure-properties relationship, 17th International Conference of Physical Chemistry-ROMPHYSCHEM, Bucuresti, Romania, 25-27 September 2023


    Awards

    1. A. Filimon, L. Lupa, D. Serbezeanu, A.M. Dobos, O. Dumbrava, Improved technologies for the development of electrospun polysulfone membranes integrated in an extracorporeal device applicable in renal failure, 27th International Exhibition of Inventions "INVENTICA 2023", Iasi, Romania, 21-23 June 2023, (Diploma of Honor, Gold medal)
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    Stage 3 (2024)

    Estimated results:

  • 2 accepted/published ISI scientific papers (accomplished)
  • 1 ISI scientific work sent for publication (accomplished)
  • 1 participation at international/national conferences (accomplished)
  • 1 patent application (accomplished)



    • Obtained results:


    Papers published in ISI journals:

    1. A. Filimon, D. Serbezeanu, A.M. Dobos, M.D. Onofrei, A. Bargan, D. Rusu, C.M. Rimbu, Electrospun membranes based on quaternized polysulfones: Rheological properties-electrospinning mechanisms relationship, Polymers, 16, 2024, 1503. (DOI:10.3390/polym16111503)
    2. E. Perju, D. Serbezeanu, M. Homocianu, M. Avadanei, T. Vlad-Bubulac, Differential insights into structural dynamics and photophysical behavior of two phosphorus containing diesters, New J. Chem., 48, 2024, 11864-11873. (DOI: 10.1039/d4nj01844c)
    3. L. Lupa, A.M. Dobos, D. Serbezeanu, D. Rusu, D. Suflet, A. Filimon, Performance and functionality of the polysulfone electrospun membranes in hemodialysis: Control and evaluation of the surface and permeation properties, Mater. Des., 2024 (under review)
    4. A. Filimon, D. Serbezeanu, I. Rosca, D. Peptanariu, M.D. Onofrei, V. Balan, Biological response of the electrospun membranes based on functionalized polysulfones for application in renal failure: In vitro cytocompatibility and blood compatibility, Biomaterials, 2024 (under review)


    Participations at conferences:

    1. A.M. Dobos, D. Serbezeanu, D. Rusu, M.D. Onofrei, A. Bargan, A.-M. Macsim, L. Lupa, A. Filimon, Bioactive fibrous membranes based on polysulfones: Evaluation of the surface and permeation properties, Congresul International al Universitatii "Apollonia" din Iasi, Pregatim viitorul promovand excelenta, Editia a XXXIV-a, Iasi, Romania, 29 February-3 March 2024 (poster)
    2. D. Serbezeanu, I. Rosca, D. Peptanariu, M. Aflori, A. M. Dobos, O. Dumbrava, A. Filimon, Performance of the polysulfonic fibrous membranes in biomedical applications: Cell-material interaction and antimicrobial activity, Congresul International al Universitatii "Apollonia" din Iasi, Pregatim viitorul promovand excelenta, Editia a XXXIV-a, Iasi, Romania, 29 February-3 March 2024 (poster)



    Patent application:

    1. A. Filimon, D. Serbezeanu, A.M. Dobos, M.D. Onofrei, D. Peptanariu, L. Lupa, Procedeu de obtinere a membranelor fibroase pe baza de polisulfona cuaternizata functionalizate cu antioxidanti si heparina, aplicabile in procesul de hemodializa, Brever application no. 2601/17.06.2024


    Other activities:

    1. Lorena Draganesc, Testarea membranelor semipermeabile in procesul de indepartare a ureei, creatininei si acidului uric, Bachelor thesis (2024), Scientific coordinators: L. Lupa, A. Filimon



    Contact Us

    Project director: dr. Anca FILIMON (Coordonator - ICMPP)

    E-mail: afilimon@icmpp.ro

    Team Coordinator:
    Conf. univ. dr. ing. Lavinia LUPA (Partner 1 - UPT)

    E-mail: lavinia.lupa@upt.ro


    Team:

    "Petru Poni" Institute of Macromolecular Chemistry, Iasi (Coordinator)

  • Dr. Anca FILIMON - Project director
  • Dr. Adina Maria DOBOS
  • Dr. Diana SERBEZEANU
  • Dr. Irina ROSCA
  • Dr. Dragos PEPTANARIU
  • Dr. Alexandra BARGAN
  • Dr. Mihaela Dorina ONOFREI
  • Drd. Oana DUMBRAVA




    • Politehnica University Timisoara (Partner 1)

  • Conf. univ. dr. ing. Lavinia LUPA - Team Coordinator
  • Prof. dr. ing. Petru NEGREA
  • Drd. Ioan-Bogdan PASCU