Natural product based heterocyclic hybrids as new antimicrobial agents: Modern solutions to long-standing challenges
Acronym: NATPHERA

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TEAM Project

Petru Poni Institute of Macromolecular Chemistry, Iași
 

Cristina Maria Al-Matarneh

Principal investigator

- organic synthesis of N-heterocycle compounds;
- advanced knowledge in structural characterization techniques FT-IR, NMR, MS and X-Ray crystallography data interpretation;
- proficiency in biological applications;
- utilization of molecular simulation techniques to study the behavior and interactions of biologically active molecules, contributing to a deeper understanding of their mechanisms and potential applications.

 
 

Alina Nicolescu
Researcher Member

- structural studies and adaptation of pulse sequences and NMR experiments for the study of organic, organometallic, macromolecular compound as well as particular expertise in NMR studies of host-guest interactions;

 
 

Anca Petrovici
Researcher Member

- determination of antioxidant properties of active -compounds from ex vivo, in vitro and in vivo media;
- controlled release studies by HPLC-ESI-MS;

 
 

Natalia Simionescu
Postdoctoral Member

- hand-on experience in cell culture techniques and biological assessments like: in vitro biocompatibility/cytotoxicity and intracellular antioxidant activity of biological and synthetic compounds, in vitro biological evaluation of medical devices, ELISA and molecular biology;

 
 

Savu Marius
PhD student

- organic synthesis of N-heterocycle compounds;
- structural characterization techniques FT-IR, NMR, MS and X-Ray crystallography data interpretation

 
 
Partner - Moldova State University
 
 

Veaceslav Kulcițki
Responsable partner

- chemistry of terpenoids;
- synthesis of natural terpenoids with biological activity;
- diversity oriented synthesis of terpenoids via ionic and free radical transformations;
- application of HPLC, NMR, GC–MS methods for the analysis and isolation of secondary metabolites from plant sources;

 
 

Vladilena Girbu
Postdoctoral Member

- chemistry of natural compounds;
- radical and photo-functionalization of natural products;
- characterization techniques NMR, GCMS, IR and HPLC data interpretation;
- functionalization of C-H bonds, with the introduction of various F, N3, I etc. groups via radical reactions;

 
 

Marina Grinco
Researcher Member

-advanced organic synthesis; chemistry of natural and biologically active compounds;
-isolation, structural elucidation, and chemical modification of plant secondary metabolites;
-physico-chemical methods of analysis;

 
 

Ana Popuşoi
Postdoctoral Member

- natural products chemistry;
- radical and photochemistry;
- C–H bond functionalization and fluorination;
- chemistry of isothiocyanatopropenones and thiourea derivatives;

 
 
NATPHERA
The project leading to this application has received funding from the Ministry of Research, Innovation and Digitization